Projects
AADC enzyme activity
AADC enzyme activity in de novo Parkinson’s disease.
Main applicant: Prof. dr. Marcel Verbeek
Affiliation(s): Radboudumc (NL).
Abstract: Biomarkers for early identification of PD are scarce. Previous studies have shown that persons with PD, between 2 and 12 years of disease duration, have increased blood AADC enzyme activity levels. We aim to study if blood levels of the AADC enzyme activity are also increased in PD patients at early stage of the disease, and may therefore serve as an early biomarker of PD.
Related Publications: Mechanisms of peripheral levodopa resistance in Parkinson’s disease.