Neural markers of Freezing of Gait in Parkinson’s Disease.
Main applicant: Asst. Prof. Moran Gilat
Affiliation(s): KU Leuven (BE)
Abstract: This study aims to uncover neural markers of Freezing of Gait (FOG) in Parkinson’s disease (PD). FOG is notoriously difficult to treat once it develops and therefore early risk detection and intervention may be a more effective strategy. So far, research on the neural changes preceding the onset of FOG are limited, due to small datasets with poor FOG characterization. Using clinical and MRI data from the PPP, we will objectively characterize FOG and investigate the structural and functional connectivity changes predictive of future FOG development. We anticipate that this work will uncover novel and generalizable neural markers of FOG risk in PD.
Related Publications: Freezing of gait in Parkinson’s disease: pathophysiology, risk factors and treatments.