Vitamin B6, B9, and B12 intake in relation to Parkinson's disease progression in patients on Levodopa medication
Main applicant: Dr. Pol Grootswagers
Affiliation(s): Wageningen University (NL)
Abstract: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, which has severe consequences, as it is chronic and incurable. Previous research shows that some B-vitamins are associated with decreased risk of PD. However, the role of B-vitamin intake on the progression of PD, such as cognitive- and motor functioning, remains unclear. Vitamin B6, B9, and B12 are involved in the homocysteine (Hcy) metabolism, and sufficient intake relates to lower Hcy levels. Hcy levels are increased in PD patients and have been linked to cardio- and cerebrovascular events and reduced cognitive function. Lower Hcy levels and higher vitamin B6, B9, and B12 intake could therefore slow the progression of PD.
Research question: This thesis investigates the individual associations between vitamin B6, B9, and B12 intake via food and the progression of PD in patients on Levodopa medication.
Methods: Data from the Personalized Parkinson Project (PPP) will be used, in which 517 patients ≥ 18 years with PD were included with a PD duration ≤5 years. Of these patients, FFQ data of 253 patients were available for vitamin B intake. Progression is defined as the decline of motor- and cognitive functioning. Motor functioning was measured with the Movement Disorders Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale from the motor section (part III) in the OFF and ON state. Cognitive functioning was measured with the Montreal Cognitive Assessment scale (MoCA). Linear (mixed) models will be used to answer the research questions. Potential confounders that will be adjusted for are age, Levodopa Dose Equivalency, physical activity, sex, smoking, disease duration, energy intake, protein intake, fiber intake, Body Mass Index, and the other B-vitamins.
Related publications: ‘Role of Diet and Nutritional Supplements in Parkinson’s Disease Progression’ Role of Diet and Nutritional Supplements in Parkinson's Disease Progression - PMC