Changing rhythms In Parkinson’s disease

Development of motor and non-motor digital progression biomarkers based on continuous, real-life monitoring.

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Hidden Sorrows of Covid-19 Impact of Stress on Parkinson’s disease Progression

Parkinson’s disease (PD) is caused by progressive loss of nigro-striatal dopamine cells. Converging clinical evidence indicates that PD patients are very sensitive to the effects of psychological stress.

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Pants sign as a predictive marker For postural instability and falling in Parkinson’s disease

Postural instability is one of the clinical hallmarks of Parkinson’s disease (PD).

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ABCD-Parkinson Developing a bisulfite-sequencing assay

To estimate the concentration of cell-free DNA (cfDNA) in peripheral blood as a surrogate marker of brain cell degeneration.

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Microbiome-mitochondrial interactions Impact neuronal circuits and gut-brain connections in Parkinson’s disease (MIGUT)

Drug treatment with levodopa is the mainstay of treatment, but offers only partial symptomatic relief.

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Genetic analyses For MIGUT and JPND projects

Development of novel therapies aimed at slowing disease progression is hampered by the lack of detailed knowledge of the underlying disease mechanisms.

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