Projects

Changing rhythms In Parkinson’s disease

Development of motor and non-motor digital progression biomarkers based on continuous, real-life monitoring.

Role of neuroinflammation In progressive basal ganglia dysfunction in Parkinson’s disease

Hidden Sorrows of Covid-19 Impact of Stress on Parkinson’s disease Progression

Parkinson’s disease (PD) is caused by progressive loss of nigro-striatal dopamine cells. Converging clinical evidence indicates that PD patients are very sensitive to the effects of psychological stress.

Pants sign as a predictive marker For postural instability and falling in Parkinson’s disease

Postural instability is one of the clinical hallmarks of Parkinson’s disease (PD).

ABCD-Parkinson Developing a bisulfite-sequencing assay

To estimate the concentration of cell-free DNA (cfDNA) in peripheral blood as a surrogate marker of brain cell degeneration.

Personalized treatment of gut health To combat levodopa-resistance in persons with Parkinson’s disease

Microbiome-mitochondrial interactions Impact neuronal circuits and gut-brain connections in Parkinson’s disease (MIGUT)

Drug treatment with levodopa is the mainstay of treatment, but offers only partial symptomatic relief.

Genetic analyses For MIGUT and JPND projects

Development of novel therapies aimed at slowing disease progression is hampered by the lack of detailed knowledge of the underlying disease mechanisms.